작성일: 2009-08-28

일시: 2009. 9. 17. 오전 11시

장소: 과학관 B102

문의: 생물학과 조진원 교수(교내4083)

Searching for genes involved in common complex trait diseases

Hyoung Doo Shin DVM. Ph.D

Laboratory of Genomic Diversity

Department of Life Science, Sogang University

email: hdshin@sogang.ac.kr

The completion of the whole human genome sequences is now a reality. Recent few years have witnessed a major methodological shift from linkage to association analysis in identifying disease genes of common disorders.

Family-based linkage analysis is a powerful tool for identifying disease genes, but its success had been limited to studying rare diseases. Numerous large genome-wide linkage analyses have been performed in common disorders, but without much success. Such a difficulty is likely due to the etiological complexity of common disease, which is believed to involve multiple genetic risk factors each with very moderate effect and often interacting with environmental factors. Association analysis is promoted as a better alternative approach for studying common disorders because of its power for detecting gene risk factors with moderate effect. Much more efforts in pursuing large-scale population-based association analysis are underway in multiple laboratories around the world, and true success still need to be seen. In this talk, genome-wide and comprehensive candidate gene-based association study of various diseases will be presented as an example to discuss several strategic and methodological issues in performing large-scale association study.